無抗時代 腸道無憂

小腸——營養消化吸收的主要場所

Small intestine——The main place for nutrient digestion and absorption

    小腸上接胃幽門，下接盲腸，分為十二指腸、空腸、回腸，主要通過胰液、膽汁和小腸液的化學性消化以及小腸運動的機械系消化，將營養物質最后分解為可吸收的小分子物質，并在小腸被吸收入血液和淋巴循環。小腸絨毛的存在加大了小腸養分吸收的表面積，一旦受損則養分吸收效率大大降低。

Small intestine connects with gastric pylorus from the upper end and cecum from the lower end, divided into duodenum, jejunum and ileum. Nutrients are decomposed into absorbable small molecular substances and absorbed into blood and lymph circulation in small intestine, mainly by a chemical digestion of pancreatic juice, bile and intestinal fluid, as well as a mechanical digestion of small intestine motility. Intestinal villi expanded nutrient absorption area of small intestine, which negatively affects nutrient absorption once injured.

大腸——廢物過濾器

Large intestine——The Waste filter

大腸為消化道末端，分為盲腸、結腸、直腸三個部分。大腸主要是進一步吸收糞便中的水分、電解質及其他有用成分（揮發性脂肪酸等）。大腸杯狀細胞數量較高，分泌粘液蛋白促進糞便下行，保護腸壁，防止機械性損傷。

Large intestine is divided into cecum, colon, and rectum. It is the end of digestive tract, with a core function of absorbing water, electrolytes and other useful components (volatile fatty acids, etc.) exist in feces. A downward movement of feces, which is motivated by secreting mucus proteins as goblet cells in large intestine is high, will protect intestinal wall from a mechanical injury.

大腸內，微生物不斷地對食物殘渣進行發酵，大腸內細菌構成一個巨大而復雜的生態系統，對維持機體正常內環境具有十分重要的作用。

Microorganisms’ constant fermentation over food residues, and the huge and complex ecosystem formed by bacteria, both of these two activities that happen in large intestine play an important role in maintaining a normal internal environment of the body.

小腸、大腸組織結構比較

Comparison of tissue structure of small intestine and large intestine

在實際生產過程中，為了實現生產效益的最大化，養殖動物腸道必須高負荷的進行飼料轉化，其時時刻刻面臨損傷的危險。首先，飼料里面高蛋白等會引起腸道粘膜的應激反應；其次，時刻面臨著病原微生物的侵害；再者，生存環境的好壞，溫、濕度的變化等等都會引起腸道粘膜的損傷。

In actual production, in order to maximize the production efficiency, the intestinal tract of breeding animals must carry out feed conversion under high load, which is facing a risk of injury all the time. First of all, a high content protein in feed causes a stress reaction of intestinal mucosa; secondly, intestinal is always invaded by pathogenic microorganisms; moreover, quality of living environment and changes in temperature and humidity, etc. will cause damages to intestinal mucosa.

危機時刻存在，無抗時代，如何化解，值得思考！

The crisis always exists, the age of AGP-free, how to resolve is worth thinking!

抗生素禁用在即，替抗物質的篩選以及使用成為必然，而中、短鏈脂肪酸酯具有特有的過胃性能、較廣的抑菌譜和特有的功能營養特點。例如：三丁酸甘油酯可以實現丁酸的腸道釋放，最大限度的給腸道粘膜供應丁酸，且沒有游離丁酸就沒有了丁酸讓人討厭的臭味，完美實現不臭過胃護全腸；α-單月桂酸甘油酯作為中鏈脂肪酸酯的代表，其抑菌性能優越，針對產氣莢膜梭菌以及空腸彎曲桿菌等常見致病菌效果顯著。植物精油以及微生態制劑具有良好的廣譜抑菌性能，且對腸道粘膜免疫有其特有功效，也是替抗不錯的選擇。一些特殊的功能性氨基酸通過腸道粘膜營養供應，也可迅速修復損傷粘膜提高粘膜抗逆性，在無抗時代也值得關注。

A screening and usage of AGP substitution is becoming an inevitable move, due to the prohibition of AGP announced in China. Medium and short-chain fatty acid esters have an unique stomach-feeding performance, broader antibacterial spectrum, and functional nutritional characteristic. For instance, tributyrin starts the release of butyric acid, of which maximize the supply to intestinal mucosa, moreover, tributyrin is able to get rid of a stink smell when free butyric acid disappears, bypass the stomach 100% and protects intestine. α-monolaurin, as the typical of medium-chain fatty acid esters, has an excellent antibacterial performance, especially on Clos’tridium ‘perfringens and Campylo’bacter jejuni. With an exclusive effect on broad-spectrum antibacterial performance and intestinal mucosal immunity, both plant essential oil and probiotics are  suitable options for AGP substitution. Some certain functional amino acids can also repair damaged mucosa to improve mucosal stress resistance, by nutrient supply from intestinal mucosa, which deserves attentions as well.

三丁酸甘油酯在胃中不被分解與吸收，可以“全過胃”，特別是對主要定植于后腸和盲腸的病原菌（如沙門氏菌和產氣莢膜梭菌），抑菌效果明顯優于其他產品（如丁酸鈉）。

Tributyrin gets to pass through stomach without being decomposed or absorbed all by its special feature, and it provides an antibacterial performance that surpasses many other products, especially on the pathogens (such as Salmonella and Clostridium perfringens) are ‘colonized in hindgut and cecum.

由上表可以看到，α-單月桂酸甘油酯對產氣莢膜梭菌的敏感度非常高，產氣莢膜梭菌容易導致母豬脹氣病和壞死性腸炎。

It can be seen from the table above that α-monolaurin acid glyceride is highly sensitive to Clostridium perfringens which is easy to cause flatulence in sows and ‘necro’tizing enteritis in swine and poultry.

全面禁抗在即，腸道問題短期內必然會呈現上升趨勢。無抗時代，針對腸道問題，必須要有全盤思考，一款好的替抗產品必然是在關注小腸消化吸收的同時，一定要注重大腸的水、電解質的吸收。

     With a grand scale of AGP prohibition is approaching, intestinal problems will be in an upward trend in no time. We suggest an overall consideration should be laid on intestinal problems when we enter the AGP-free era. An adequate alternative to AGP will be required to pay attention to the absorption of water and electrolytes in large intestine, while focusing on the digestion and absorption of small intestine.

養殖就是養腸道，腸道健康養殖效益自然好!

When we say breeding, we talk about intestine protection, as an healthy intestine ensures benefits.